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Objective@#To explore the occurrence of anemia in patients with ten common malignant tumors and the related risk factors.@*Methods@#A retrospective analysis was performed in 15 612 patients with ten common malignant tumors admitted in Zhejiang Cancer Hospital from January 2016 to September 2016 by single factor analysis.@*Results@#Among the 15 612 cases, there were 7 468 males (47.83%), 8 144 females (52.17%), and anemia occurred in 5 541 cases, accounted for 35.5% of all the cases with malignancy.Ovarian cancer, gastric cancer and esophageal cancer ranked top three in all types with occurrence of 57.9%, 53.1% and 49% respectively.According to the grading, mild to moderate (Grade 1-2) anemia accounted for 91.2% of the total cancer related anemia, while severe (Grade 3-4) consisted only a small proportion of 8.8%.The mean age of malignant tumor patients was (56.1±11.6)years old, and that showed a significantly difference between the anemia group and non-anemia group in patients' ages among lung cancer, colorectal cancer, gastric cancer and nasopharyngeal carcinoma(t=7.162, 2.486, 4.353, 2.926, all P<0.05). Gender analysis showed that male patients were more prone to cancer related anemia in esophageal cancer and lung cancer(χ2=91.034, 9.240, all P<0.05), and less likely in colorectal cancer, liver cancer and thyroid cancer(χ2=7.707, 6.629, 8.700, all P<0.05) (ovarian cancer, cervix cancer and breast cancer were excluded in this section for their none or rare incidence in male).@*Conclusion@#The patients with malignancy have a relative high occurrence of anemia.Caner related anemia is rather mild to moderate than severe, and tumor types, ages and genders were the risk factors of anemia in patients with malignancy.
ABSTRACT
Objective To explore the occurrence of anemia in patients with ten common malignant tumors and the related risk factors.Methods A retrospective analysis was performed in 15 612 patients with ten common malignant tumors admitted in Zhejiang Cancer Hospital from January 2016 to September 2016 by single factor analysis.Results Among the 15 612 cases,there were 7 468 males (47.83%),8 144 females (52.17%),and anemia occurred in 5 541 cases,accounted for 35.5% of all the cases with malignancy.Ovarian cancer,gastric cancer and esophageal cancer ranked top three in all types with occurrence of 57.9%,53.1% and 49% respectively. According to the grading,mild to moderate (Grade 1 -2) anemia accounted for 91.2% of the total cancer related anemia,while severe ( Grade 3 -4) consisted only a small proportion of 8.8%.The mean age of malignant tumor patients was (56.1 ± 11.6)years old,and that showed a significantly difference between the anemia group and non-anemia group in patients＇ages among lung cancer,colorectal cancer,gastric cancer and nasopharyngeal carcinoma(t=7.162,2.486,4.353,2.926,all P＜0.05).Gender analysis showed that male patients were more prone to cancer related anemia in esophageal cancer and lung cancer(χ2 =91.034,9.240,all P＜0.05),and less likely in colorectal cancer,liver cancer and thyroid cancer(χ2 =7.707,6.629,8.700,all P＜0.05) ( ovarian cancer,cervix cancer and breast cancer were excluded in this section for their none or rare incidence in male).Conclusion The patients with malignancy have a relative high occurrence of anemia.Caner related anemia is rather mild to moderate than severe, and tumor types,ages and genders were the risk factors of anemia in patients with malignancy.
ABSTRACT
Objective To investigate the effect of Andrographis paniculata Nees(APN)extract on Coxsackievirus A16(CVA16)in vitro.Methods African green monkey kidney-derived Vero cells(Vero cells)were treated with APN extract at the concentration of 500.0,250.0,125.0,60.0,30.0,15.0,7.5 and 3.8 μg/mL,the cytotoxicity was determined with cell counting Kit-8 and the IC50was calculated by Probit unit regression method.Direct inactivating activity on CVA16,blocking of CVA16 adsorbing Vero cells and inhibition of CVA16 replication in Vero cells were determined and compared between Ribavirin(RBV) and APN extract with CVA16-infected Vero cells.SPSS 24.0 software was used to analyze the data.Results The selected concentrations of APN extract and RBV for experiment were 15.0, 7.5 and 3.8 μg/mL according to cytotoxicity test.Both of APN extract and RBV had neither direct inactivation on CVA 16 nor blocking of CVA16 adsorbing at the concentration of 15.0,7.5 and 3.8 μg/mL(F=1.54,1.52 and 0.67, 1.68,all P>0.05).However,both drugs had the capability of inhibiting CVA 16 replication in Vero cells at the concentration of 15.0 and 7.5 μg/mL(t=6.87,11.76 and 7.71,12.84,all P<0.05).Conclusion Experimental result shows that APN extract can effectively inhibit CVA 16 replication in Vero cells in vitro.